課程大綱

課程資訊

課程名稱

臨床影像及神經影像二
Clinical Imaging & Neurological Imaging(Ⅱ)

開課學期

104-2

授課對象

醫學院物理治療學研究所

授課教師

湯佩芳

課號

PT8058

課程識別碼

428 D0530

班次

學分

全/半年

半年

必/選修

選修

上課時間

星期三8,9(15:30~17:20)

上課地點

討論室一

備註

本課程中文授課,使用英文教科書。與吳瑞美、邱銘章、鄭建興、彭信逢、陳雅芳、賴達明、湯頌君、曾文毅合開
限碩士班以上
總人數上限：8人

Ceiba 課程網頁

http://ceiba.ntu.edu.tw/1042PT8058_

課程簡介影片

核心能力關聯

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課程概述

本課程目的為培育物理治療師判讀神經、血管影像的能力，以及運用神經、血管影像於物理治療臨床決策與臨床研究的能力。課程內容以介紹腦與脊髓系統之神經、血管影像為主，含：影像成像原理之介紹，正常與異常之影像判讀，以及影像如何應用於主要神經疾患(如腦中風、巴金森氏症、失智症、腦瘤、頭部外傷、水腦、脊髓損傷與病變等)之診斷、預後、治療、及研究。課程之進行採用授課、課堂討論、文獻閱讀、與個案報告並行的方式。為達最佳之學習效果，請修習學生務必事先預習每次上課的參考文獻或資料。本課程之設計涵蓋培養學生之專業與教學能力、跨領域團隊合作與領導、及創新與研究等核心能力。

課程目標

修習學生在結束本課程時，應能：
1. 瞭解電腦斷層、磁振造影、磁振血管攝影、正子攝影、與神經超音波等之影像原理；
2. 學習判讀腦與脊髓系統的神經與血管影像；
3. 瞭解神經、血管影像判讀結果與臨床表徵間的關係；
4. 學習應用神經、血管影像資訊於神經物理治療主要臨床疾病類別(main functional diagnosis classifications or categories)之功能性診斷、預後、與治療臨床決策。

課程要求

本課程包含課堂報告及討論、期中文獻報告、期末口頭報告以及期末書面報告。

預期每週課後學習時數

Office Hours

指定閱讀

待補

參考書目

I. Neuroanatomy and neuroscience textbooks
A. Bear M, Connors B, Paradiso M. Neuroscience: Exploring the brain, 3 ed.
Baltimore: Lippincott Williams & Wilkins. 2016.
B. Haines DE. Neuroanatomy: An atlas of structures, sections, and systems
(8th ed). Philadelphia: Wolters Kluwer Health/ Lippincott Williams & Wilkins. 2012.
C. Mai JK, Paxinos G, Voss T. Atlas of the human brain (3rd ed). New York:
Academic Press. 2008.
D. Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia A-W, White LE.
Editors. Neuroscience. 5th ed, Sunderland, MA, USA: Sinaur Associates, Inc.
2012.
E. Lundy-Ekman L. Neuroscience: Fundamentals for Rehabilitation 4th. ed. St.
Louis, Missouri: Saunders Co. 2012.
II. Neuroimaging textbooks
A. Gillard JH, Waldman AD, and Barker PB. Clinical MR neuroimaging:
Physiological and functional techniques (2nd ed). New York: Cambridge University Press. 2010.
B. Naidich TP. Duvernoy's atlas of the human brain stem and cerebellum
[electronic resource]: High-field MRI: Surface anatomy, internal structure, vascularization and 3D sectional anatomy. Vienna: Springer Vienna. 2009.
C. Westbrook C, Roth CK, TalbotJ. MRI in practice (4th ed). Chichester, West
Sussex ; Malden, MA : Wiley-Blackwell. 2011.
D. Westbrook C. MRI at a glance (2nd ed). Chichester, U.K. ; Malden, MA
:Wiley-Blackwell. 2010.
E. 陳煥武編譯(Catherine Westbrook 原著)。圖解核磁共振造影學。台北市:合記。2006。
F. Scott W. Atlas (Editor). Magnetic resonance imaging of the brain and
spine. 4th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.
G. Scott W. Atlas (Editor) MRI of the brain and spine [electronic resource].
Philadelphia: Lippincott Williams & Wilkins. 2008.
III. Readings of neuroimaging articles: basic principles and imaging of
specific neurological disorders
A. Basic principles of neuroimaging
1. Goldman LW. Principles of CT and CT technology. J Nucl Med Technol
2007;35:115-128; quiz 129-130.
2. Currie S, Hoggard N, Craven IJ, Hadjivassiliou M, Wilkinson ID.
Understanding MRI: basic MR physics for physicians. Postgrad Med J 2013;89:209-223.
3. Townsend DW. Physical principles and technology of clinical PET imaging.
Ann Acad Med Singapore 2004;33:133-145.
B. Stroke
1. Merino JG, Warach S. Imaging of acute stroke. Nat Rev Neurol 2010;6:560-
571.
2. Warren DJ, Musson R, Connolly DJ, Griffiths PD, Hoggard N. Imaging in
acute ischaemic stroke: essential for modern stroke care. Postgrad Med J 2010;86:409-418.
3. Schellinger PD, Jansen O, Fiebach JB, Hacke W, Sartor K. A standardized
MRI Stroke protocol comparison with CT in hyperacute intracerebral
hemorrhage. Stroke 1999;30:765-768.
4. Wilde EA, Hunter JV, Bigler ED. A primer of neuroimaging analysis in
neurorehabilitation outcome research. NeuroRehabilitation 2012;31:227-242.
C. Cervical myelopathy
1. Ellingson BM, Salamon N, Hardy AJ, Holly LT. Prediction of neurological
Impairment in cervical spondylotic myelopathy using a Combination of
Diffusion MRI and Proton MR Spectroscopy. PLoS One 2015;10:e0139451.
2. Ellingson BM, Salamon N, Holly LT. Advances in MR imaging for cervical
spondylotic myelopathy. Eur Spine J 2013.
D. Parkinson’s disease
1. Stoessl AJ. Neuroimaging in Parkinson's disease: from pathology to
diagnosis. Parkinsonism & related disorders 2012;18 Suppl 1:S55-59.
2. Lu CS, Weng YH, Chen MC, et al. 99mTc-TRODAT-1 imaging of multiple
system atrophy. J Nucl Med 2004;45:49-55.
3. Weng YH, Yen TC, Chen MC, et al. Sensitivity and specificity of 99mTc-
TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects. J Nucl Med 2004;45:393-401.
4. Huang WS, Lee MS, Lin JC, et al. Usefulness of brain 99mTc-TRODAT-1 SPET
for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging 2004;31:155-161.
5. Fallahi B, Esmaeili A, Beiki D, et al. Evaluation of (99m)Tc-TRODAT-1
SPECT in the diagnosis of Parkinson's disease versus other progressive movement disorders. Ann Nucl Med 2016;30:153-162.
E. Dementia
1. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal
abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351-356.
2. Scheltens P, Launer LJ, Barkhof F, Weinstein HC, van Gool WA. Visual
assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol 1995;242:557-560.
3. Mortimer AM, Likeman M, Lewis TT. Neuroimaging in dementia: a practical
guide. Practical neurology 2013;13:92-103.
4. Schroder J, Pantel J. Neuroimaging of hippocampal atrophy in early
recognition of Alzheimer s disease - a critical appraisal after two decades of research. Psychiatry Res 2016;247:71-78.
IV. Other electronic resources
1. de Asis Bravo-Rodriguez F, Diaz-Aguilera R. Hygino Cruz Jr. LC. (Editors)
Learning neuroimaging [electronic resource]: 100 essential cases. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg. 2012.
2. Espinosa PS, Smith CD. Neurology Self-Assessment: Focus on Neuroimaging
[electronic resource]. Philadelphia: Lippincott Williams & Wilkins. 2009.(叢
書名 Neurology self-assessment)
3. Barkovich AJ, Raybaud C. Pediatric neuroimaging [electronic resource].
Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2012.
4. Barkhof F. et al. Neuroimaging in dementia [electronic resource]. Berlin,
Heidelberg : Springer-Verlag Berlin Heidelberg. 2011.
5. Rabinstein AA and Resnick SJ. Practical neuroimaging in stroke: A case-
based approach. Philadelphia, PA: Saunders/Elsevier. 2009. (WL356 R116p 2009 3183875)

評量方式
(僅供參考)

No.	項目	百分比	說明
1.	上課參與、報告、及討論	30%
2.	期中文獻報告	20%
3.	期末口頭報告	25%
4.	期末書面報告	25%

課程進度

週次	日期	單元主題
第1週	2/24	Course overview Review of Anatomy and Function of the Brain and Spinal Cord (I)
第2週	3/02	Review of Anatomy and Function of the Brain and Spinal Cord (II) 學生報告
第3週	3/09	Review of Anatomy and Function of the Brain and Spinal Cord (III)- using brain slices 學生報告
第4週	3/16	Review of Anatomy and Function of the Brain and Spinal Cord (IV)- using images 學生報告
第5週	3/23	Introduction to Basic Principles of CT, MRI, and PET
第6週	3/30	CT and MRI images of the adult brain and spinal cord: Guides for reading normal and pathological images
第7週	4/06	Neuroimage correlates of clinical S/S MR Angiography; NTUH Image Lab tour
第8週	4/13	期中文獻報告(in groups)
第9週	4/20	Pediatric neuroimaging
第10週	4/27	Ultrasonic imaging for neurological disorders
第11週	5/04	Neuroimaging for stroke- I. Hyperacute, acute, subacute, and chronic ischemic stroke
第12週	5/11	Neuroimaging for stroke- II. Clinical correlates and prognostic factors 學生文獻報告(in groups)
第13週	5/18	Neuroimaging for cerebral hemorrhage, hydrocephalus, brain tumor, and traumatic brain injury
第14週	5/25	Neuroimaging for spinal disorders
第15週	6/01	Neuroimaging for Parkinson’s disease and other basal ganglia disorders
第16週	6/08	Neuroimaging for dementia
第17週	6/15	Final Examination I – case studies (by individual)
第18週	06/22	Final Examination II – case studies (by individual)